Abstract
Three-dimensional data are increasingly prevalent across biomedical and social domains. Notable examples are gene-sample-time, individual-feature-time, or node-node-time data, generally referred to as observation-attribute-context data. The unsupervised analysis of three-dimensional data can be pursued to discover putative biological modules, disease progression profiles, and communities of individuals with coherent behavior, among other patterns of interest. It is thus key to enhance the understanding of complex biological, individual, and societal systems. In this context, although clustering can be applied to group observations, its relevance is limited since observations in three-dimensional data domains are typically only meaningfully correlated on subspaces of the overall space. Biclustering tackles this challenge but disregards the third dimension. In this scenario, triclustering—the discovery of coherent subspaces within three-dimensional data—has been largely researched to tackle these problems. Despite the diversity of contributions in this field, there still lacks a structured view on the major requirements of triclustering, desirable forms of homogeneity (including coherency, structure, quality, locality, and orthonormality criteria), and algorithmic approaches. This work formalizes the triclustering task and its scope, introduces a taxonomy to categorize the contributions in the field, provides a comprehensive comparison of state-of-the-art triclustering algorithms according to their behavior and output, and lists relevant real-world applications. Finally, it highlights challenges and opportunities to advance the field of triclustering and its applicability to complex three-dimensional data analysis.
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Index Terms
- Triclustering Algorithms for Three-Dimensional Data Analysis: A Comprehensive Survey
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Highlights- THD-Tricluster mines co-expressed genes, exhibiting shifting-and-scaling patterns.
AbstractDeveloping a cost-effective and robust triclustering algorithm that can identify triclusters of high biological significance in the gene-sample-time (GST) domain is a challenging task. Most existing triclustering algorithms can detect ...
Dual-Stream Subspace Clustering Network for revealing gene targets in Alzheimer's disease
AbstractThe rapid development of scRNA-seq technology in recent years has enabled us to capture high-throughput gene expression profiles at single-cell resolution, reveal the heterogeneity of complex cell populations, and greatly advance our ...
Highlights- We have proposed a novel Dual-Stream Subspace Clustering Network method, DS-SCNet.
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