Synthesis of copper nanoparticles by thermal decomposition and their antimicrobial properties

Abstract

Copper nanoparticles were synthesized by thermal decomposition using copper chloride, sodiumoleate, and phenyl ether as solvent agents. The formation of nanoparticles was evidenced by the X-ray diffraction and transmission electron microscopy. The peaks in the XRD pattern correspond to the standard values of the face centered cubic (fcc) structure of metallic copper and no peaks of other impurity crystalline phases were detected. TEM analysis showed spherical nanoparticles with sizes in the range of 4 to 18 nm. The antibacterial properties of copper nanoparticles were evaluated in vitro against strains of Staphylococcus aureus and Pseudomonas aeruginosa. The antibacterial activity of copper nanoparticles synthesized by thermal decomposition showed significant inhibitory effect against these highly multidrug-resistant bacterial strains.

References

1. J. P. Ruparelia, A. K. Chatterjee, S. P. Duttagupta, and S. Mukherji, "Strain specificity in antimicrobial activity of silver and copper nanoparticles," Acta Biomaterialia, vol. 4, no. 3, pp. 707-716, 2008.
2. G. Ren, D. Hu, E. W. C. Cheng, M. A. Vargas-Reus, P. Reip, and R. P. Allaker, "Characterisation of copper oxide nanoparticles for antimicrobial applications," The International Journal of Antimicrobial Agents, vol. 33, no. 6, pp. 587-590, 2009.
3. K. Y. Yoon, J. H. Byeon, J. H. Park, and J. Hwang, "Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles," Science of the Total Environment, vol. 373, no. 2-3, pp. 572-575, 2007.
4. B. L. Cushing, V. L. Kolesnichenko, and C. J. O'Connor, "Recent advances in the liquid-phase syntheses of inorganic nanoparticles," Chemical Reviews, vol. 104, no. 9, pp. 3893-3946, 2004.
5. P. Tartaj, M. del Puerto Morales, S. Veintemillas-Verdaguer, T. González-Carreño, and C. J. Serna, "The preparation of magnetic nanoparticles for applications in biomedicine," Journal of Physics D, vol. 36, no. 13, pp. R182-R197, 2003.
6. J. Xie, S. Peng, N. Brower, N. Pourmand, S.X. Wang, and S. Sun, "One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications," Pure and Applied Chemistry, vol. 78, no. 5, pp. 1003-1014, 2006.
7. A. G. Roca, M. P. Morales, and C. J. Serna, "Synthesis of monodispersed magnetite particle from different precursors," IEEE Transactions on Magnetics, vol. 42, no. 10, pp. 3025-3040.
8. S. Sun, H. Zeng, D. B. Robinson et al., "Monodisperse MFe₂O₄ (M = Fe, Co, Mn) nanoparticles," Journal of the American Chemical Society, vol. 126, no. 1, pp. 273-279, 2004.
9. P. Guardia, B. Batlle-Brugal, A. G. Roca et al., "Surfactant effects in magnetite nanoparticles of controlled size," Journal of Magnetism and Magnetic Materials, vol. 316, no. 2, pp. e756- e759, 2007.
10. A. G. Roca, M. P. Morales, K. O'Grady, and C. J. Serna, "Structural and magnetic properties of uniform magnetite nanoparticles prepared by high temperature decomposition of organic precursors," Nanotechnology, vol. 17, no. 11, pp. 2783- 2788, 2006.
11. S. Sun and H. Zeng, "Size-controlled synthesis of magnetite nanoparticles," Journal of the American Chemical Society, vol. 124, no. 28, pp. 8204-8205, 2002.
12. M. Raffi, S. Mehrwan, T. M. Bhatti et al., "Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli," Annals of Microbiology, vol. 60,no. 1, pp. 75-80, 2010.
13. D. Adner, M. Korb, S. Schulze, M. Hietschold, and H. Lang, "A straightforward approach to oxide-free copper nanoparticles by thermal decomposition of a copper(I) precursor," Chemical Communications, vol. 49, pp. 6855-6857, 2013.
14. H. Wisplinghoff, H. Seifert, S. Tallent, T. Bischoff, R. Wenzel, and M. B. Edmond, "Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities," Pediatric Infectious Disease Journal, vol. 22, no. 8, pp. 686-691, 2003.
15. M. Salavati-Niasari, F. Davar, and N. Mir, "Synthesis and characterization of metallic copper nanoparticles via thermal decomposition," Polyhedron, vol. 27, no. 17, pp. 3514-3518, 2008.
16. N. Cioffi, L. Torsi, N. Ditaranto et al., "Copper nanoparticle/ polymer composites with antifungal and bacteriostatic properties," Chemistry of Materials, vol. 17, no. 21, pp. 5255-5262, 2005.
17. J. Ramyadevi, K. Jeyasubramanian, A. Marikani, G. Rajakumar, and A. A. Rahuman, "Synthesis and antimicrobial activity of copper nanoparticles," Materials Letters, vol. 71, pp. 114-116, 2012.
18. J. R. Morones, J. L. Elechiguerra, A. Camacho et al., "The bactericidal effect of silver nanoparticles," Nanotechnology, vol. 16, no. 10, pp. 2346-2353, 2005.
19. M. Guzman, J. Dille, and S. Godet, "Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gramnegative bacteria," Nanomedicine, vol. 8, no. 1, pp. 37-45, 2012.
20. G. Ren, D. Hu, E. W. C. Cheng, M. A. Vargas-Reus, P. Reip, and R. P. Allaker, "Characterisation of copper oxide nanoparticles for antimicrobial applications," The International Journal of Antimicrobial Agents, vol. 33, no. 6, pp. 587-590, 2009.
21. A. Azam, A. S. Ahmed, M. Oves, M. S. Khan, S. S. Habib, and A. Memic, "Antimicrobial activity of metal oxide nanoparticles against Gram-positive and Gram-negative bacteria: a comparative study," The International Journal of Nanomedicine, vol. 7, pp. 6003-6009, 2012.

Index Terms

• Applied computing

  • Physical sciences and engineering

    • Chemistry

• Hardware

  • Electronic design automation

    • Physical design (EDA)

• Networks

  • Network types

    • Ad hoc networks

      • Mobile ad hoc networks